PED114_EN

Project Name: Magnetic-luminescent Fe-Si hybrid nanoparticles designed for biomedical aplications (EN)

Contract no. 114/2016

Project code: PN-III-P2-2.1-PED-2016-1698

Program: Pr. 2 – Competitiveness increasing of Romanian economy through research, development and innovation.

Project type: Experimental-demonstrative project

Project director: Dumitrache Florian

Coordinator: National Institute for Lasers, Plasma, and Radiation Physics

Financing Authority: Executive Unit for Financing Higher Education, Research, Development and Innovation (UEFISCDI)

Project summary:

The project intends to develop and optimize magnetically-operable, luminescent nanoparticles for multifunctional purposes (diagnosis, drug distribution, hyperthermia and photodynamic treatment) based on hybrid Fe-Si nanoparticles. The development of the original laboratory-validated system consists on obtaining a stabilized and bio-tested suspension based on Fe-Si nanoparticles synthesized by laser pyrolysis, in a single step. The project proposes two nanostructure configurations: aggregated nanoparticles containing separate Si and Fe nanocrystals or Fe-core composite nanoparticles covered in Si-based shell. Thus, a dual material is obtained: magnetic (virtue of Fe) and luminescent (Q-dot Si). It is intended to adapt the average size of Si nanocrystals to values between 2-5 nm in order to generate visible luminescence. The nanoparticles produced will be dispersed and stabilized using derivatives of PEG, L-Dopa, CMCNa, threonine, dextran, chitosan, etc. Finally, the optimized product demonstration model will be validated on the basis of 6 characteristics: nanoparticle size, magnetic response parameters, photoluminescence efficiency, suspension stability, biocompatibility, and magnetic induced hyperthermia effect.

Phase I - 29/12/2017
Iron based and hybrid Fe / Si nanocrystals synthesized by laser pyrolysis: structure, magnetic and biocompatibility analysis.

Please click here to view phase details

PROJECT STAFF

Coordinator:
Florian Dumitrache
Claudiu Fleaca
Ion Morjan
Elena Dutu
Alina Ilie
Ion Sandu
Iuliana Morjan
Eugenia Vasile
Adrian Petris
Mihai Patachia
Dan Adrian Miron
Stefan George Banita

Partner:
Anca Dinischiotu
Sorina Nicoleta Voicu
Miruna Silvia Stan
Virginia Cecilia Gheran
Mihaela Balas
Claudia Ion