Project Name: Magnetic-luminescent Fe-Si hybrid nanoparticles designed for biomedical aplications (EN)

Contract no. 114/2016

Project code: PN-III-P2-2.1-PED-2016-1698

Program: Pr. 2 – Competitiveness increasing of Romanian economy through research, development and innovation.

Project type: Experimental-demonstrative project

Project director: Dumitrache Florian

Coordinator: National Institute for Lasers, Plasma, and Radiation Physics

Financing Authority: Executive Unit for Financing Higher Education, Research, Development and Innovation (UEFISCDI)

Project summary:

The project intends to develop and optimize magnetically-operable, luminescent nanoparticles for multifunctional purposes (diagnosis, drug distribution, hyperthermia and photodynamic treatment) based on hybrid Fe-Si nanoparticles. The development of the original laboratory-validated system consists on obtaining a stabilized and bio-tested suspension based on Fe-Si nanoparticles synthesized by laser pyrolysis, in a single step. The project proposes two nanostructure configurations: aggregated nanoparticles containing separate Si and Fe nanocrystals or Fe-core composite nanoparticles covered in Si-based shell. Thus, a dual material is obtained: magnetic (virtue of Fe) and luminescent (Q-dot Si). It is intended to adapt the average size of Si nanocrystals to values between 2-5 nm in order to generate visible luminescence. The nanoparticles produced will be dispersed and stabilized using derivatives of PEG, L-Dopa, CMCNa, threonine, dextran, chitosan, etc. Finally, the optimized product demonstration model will be validated on the basis of 6 characteristics: nanoparticle size, magnetic response parameters, photoluminescence efficiency, suspension stability, biocompatibility, and magnetic induced hyperthermia effect.

Phase I - 29/12/2017
Iron based and hybrid Fe / Si nanocrystals synthesized by laser pyrolysis: structure, magnetic and biocompatibility analysis
Please click here to view phase details

Phase I Duration: 03/01/2017 - 29/12/2017
Value allocated to Phase I from the state budget for 2017: 406,415 RON.


The results obtained during this phase were presented at 2
International Conferences, and were brought together in 2 Scientific

• L. Gavrila-Florescu, F. Dumitrache, M.Balas, C.T. Fleaca, M.Scarisoreanu, I.P. Morjan, E. Dutu, A. Ilie, A.-M. Banici, C. Locovei, G. Prodan, "Synthesis of Fe-based Core @ ZnO shell nanopowders by laser pyrolysis for biomedical applications", Applied Physics A (2017) 123: 802.
• A review article "Synthesis, characterization and in vitro biological evaluation of hybrid Fe / Si nanoparticles" at the Journal of Nanoparticle Research (Nano-D-17-02078).

International Conferences:
• Poster presentation: L. Gavrila-Florescu, F. Dumitrache, M. Balas, C. Fleaca, C. Locovei, I.P. Morjan, M.Scarisoreanu, A. Ilie, A. Banici, G. Prodan, "Synthesis by laser pyrolysis of Fe based core @ ZnO shell nanopowders for biomedical applications", EMRS Spring Meeting 2017, June 21-27, France - Strasbourg, Symposium X.
• Oral presentation: F. Dumitrache, M. Balas, C. Fleaca, I. Morjan, A. Dimischiotu, M.S. Stan, I. Sandu, A. Ilie, C. Locovei, IP Morjan, E. Vasile, O. Marinica, "Magnetic and biocompatible tests of novel iron nitride based nanoparticles synthesized by ammonia sensitized laser pyrolysis", EMRS Spring Meeting 2017, 21 June 27, France - Strasbourg,
Symposium X.


Florian Dumitrache
Claudiu Fleaca
Ion Morjan
Elena Dutu
Alina Ilie
Ion Sandu
Iuliana Morjan
Eugenia Vasile
Adrian Petris
Mihai Patachia
Dan Adrian Miron
Stefan George Banita

Anca Dinischiotu
Sorina Nicoleta Voicu
Miruna Silvia Stan
Virginia Cecilia Gheran
Mihaela Balas
Claudia Ion