PED114_EN

Project Name: Magnetic-luminescent Fe-Si hybrid nanoparticles designed for biomedical aplications (EN)

Contract no. 114/2016

Project code: PN-III-P2-2.1-PED-2016-1698

Program: Pr. 2 – Competitiveness increasing of Romanian economy through research, development and innovation.

Project type: Experimental-demonstrative project

Project director: Dumitrache Florian

Coordinator: National Institute for Lasers, Plasma, and Radiation Physics

Financing Authority: Executive Unit for Financing Higher Education, Research, Development and Innovation (UEFISCDI)

Project summary:

The project intends to develop and optimize magnetically-operable, luminescent nanoparticles for multifunctional purposes (diagnosis, drug distribution, hyperthermia and photodynamic treatment) based on hybrid Fe-Si nanoparticles. The development of the original laboratory-validated system consists on obtaining a stabilized and bio-tested suspension based on Fe-Si nanoparticles synthesized by laser pyrolysis, in a single step. The project proposes two nanostructure configurations: aggregated nanoparticles containing separate Si and Fe nanocrystals or Fe-core composite nanoparticles covered in Si-based shell. Thus, a dual material is obtained: magnetic (virtue of Fe) and luminescent (Q-dot Si). It is intended to adapt the average size of Si nanocrystals to values between 2-5 nm in order to generate visible luminescence. The nanoparticles produced will be dispersed and stabilized using derivatives of PEG, L-Dopa, CMCNa, threonine, dextran, chitosan, etc. Finally, the optimized product demonstration model will be validated on the basis of 6 characteristics: nanoparticle size, magnetic response parameters, photoluminescence efficiency, suspension stability, biocompatibility, and magnetic induced hyperthermia effect.

Phase I - 29/12/2017
Iron based and hybrid Fe / Si nanocrystals synthesized by laser pyrolysis: structure, magnetic and biocompatibility analysis
Please click here to view phase details

Phase I Duration: 03/01/2017 - 29/12/2017
Value allocated to Phase I from the state budget for 2017: 406,415 RON.

Dissemination:

The results obtained during this phase were presented at 2
International Conferences, and were brought together in 2 Scientific
Articles:

• L. Gavrila-Florescu, F. Dumitrache, M.Balas, C.T. Fleaca, M.Scarisoreanu, I.P. Morjan, E. Dutu, A. Ilie, A.-M. Banici, C. Locovei, G. Prodan, "Synthesis of Fe-based Core @ ZnO shell nanopowders by laser pyrolysis for biomedical applications", Applied Physics A (2017) 123: 802.
• A review article "Synthesis, characterization and in vitro biological evaluation of hybrid Fe / Si nanoparticles" at the Journal of Nanoparticle Research (Nano-D-17-02078).

International Conferences:
• Poster presentation: L. Gavrila-Florescu, F. Dumitrache, M. Balas, C. Fleaca, C. Locovei, I.P. Morjan, M.Scarisoreanu, A. Ilie, A. Banici, G. Prodan, "Synthesis by laser pyrolysis of Fe based core @ ZnO shell nanopowders for biomedical applications", EMRS Spring Meeting 2017, June 21-27, France - Strasbourg, Symposium X.
• Oral presentation: F. Dumitrache, M. Balas, C. Fleaca, I. Morjan, A. Dimischiotu, M.S. Stan, I. Sandu, A. Ilie, C. Locovei, IP Morjan, E. Vasile, O. Marinica, "Magnetic and biocompatible tests of novel iron nitride based nanoparticles synthesized by ammonia sensitized laser pyrolysis", EMRS Spring Meeting 2017, 21 June 27, France - Strasbourg,
Symposium X.

PROJECT STAFF

Coordinator:
Florian Dumitrache
Claudiu Fleaca
Ion Morjan
Elena Dutu
Alina Ilie
Ion Sandu
Iuliana Morjan
Eugenia Vasile
Adrian Petris
Mihai Patachia
Dan Adrian Miron
Stefan George Banita

Partner:
Anca Dinischiotu
Sorina Nicoleta Voicu
Miruna Silvia Stan
Virginia Cecilia Gheran
Mihaela Balas
Claudia Ion